代谢相关脂肪性肝病与2型糖尿病的相关性研究进展
Research progress on the correlation between metabolic-associated fatty liver disease and type 2 diabetes mellitus
赵娅芳 1杨晋辉 1郑梦瑶 1杨黎宏1
作者信息
- 1. 昆明医科大学第二附属医院消化内科,云南 昆明 650101
- 折叠
摘要
代谢相关脂肪性肝病(metabolic-associated fatty liver disease,MAFLD)和 2 型糖尿病(type 2 diabetes mellitus,T2DM)是两种常见的代谢性疾病,在全球范围内均有较高的个体患病率,二者合并的患病率呈上升趋势.MAFLD 与 T2DM 之间存在着复杂而紧密的联系,互为因果,共同促进心血管疾病、慢性肾病、肝脏相关并发症及肝外恶性肿瘤的发病.本文从流行病学、危险因素、病理生理机制、治疗等方面介绍了 MAFLD与 T2DM 之间的相关性.研究表明二者存在强烈的双向关系,MAFLD 是 T2DM 的独立危险因素,并且这种风险随着肝脏脂肪沉积的增加而增加,同时,T2DM 也可促进 MAFLD的发生发展.因此,在防治 MAFLD 的同时,也要重视 T2DM 的管理,以期提高患者的整体健康水平.
Abstract
Metabolic-associated fatty liver disease(MAFLD)and type 2 diabetes mellitus(T2DM)is two common metabolic diseases with high individual prevalence worldwide,and the combined prevalence of the two diseases is on the rise.There is a complex and close association between MAFLD and T2DM,which is reciprocal causation and jointly promotes the incidence of cardiovascular disease,chronic kidney disease,liver-related complications and extrahepatic malignancies.This article introduced the correlation between MAFLD and T2DM from the aspects of epidemiology,risk factors,pathogenesis and therapy.The research shows that there is a strong bidirectional relationship between them.MAFLD was an independent risk factor for T2DM,and this risk increased with the increase of liver fat deposition.More-over,T2DM also promoted the occurrence and progression of MAFLD.Therefore,while preventing and treating MAFLD,we should also pay attention to the management of T2DM to improve the overall health of patients.
关键词
代谢相关脂肪性肝病/2型糖尿病/流行病学/发病机制/治疗Key words
Metabolic-associated fatty liver disease/Type 2 diabetes mellitus/Epidemiology/Pathogenesis/Therapy引用本文复制引用
基金项目
国家自然科学基金(82160106)
昆明医科大学第二附属医院院内科技计划(2021yk018)
出版年
2024
NETL
NSTL
万方数据