The regulatory relationship between lactate and immunity and its value in liver failure
Liver failure is a common clinical syndrome of severe liver disease,which belongs to one of the critical medical conditions.Immune response plays a dominant role in the pathogenesis of liver failure.Lactic acid as a target for the treatment and prediction of liver failure has not attracted enough attention.Since the emergence of the concept of″histone lactation″,lactic acid has shown great prospects in immune response and immune evasion.Therefore,targeted lactic acid may be a reliable mediator for addressing immune dysregulation and energy metabolism disorders in liver fail-ure.In this paper,based on the relationship between lactic acid and immune response,the influence mechanism of lac-tic acid metabolism and its compounds on immune cross-talk and its significance in the diagnosis and treatment of liver failure were expounded,aimed to provide new insights into the understanding and treatment of liver failure.
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