胃癌组织中lncRNA PTPRG-AS1、miR-599表达与临床病理特征及预后的关系
The relationship between the expression of lncRNA PTPRG-AS1 and miR-599 in gastric cancer tissue and clinical pathological characteristics and prognosis
曹卉 1谭婉燕 1王晓林 1余愿 2汪甜3
作者信息
- 1. 华中科技大学同济医学院附属梨园医院消化内科,湖北武汉 430077
- 2. 华中科技大学同济医学院附属协和医院消化内科
- 3. 咸宁市中心医院老年病科
- 折叠
摘要
目的 分析胃癌组织中长链非编码RNA(long non-coding RNA,lncRNA)蛋白酪氨酸磷酸酶受体G基因反义链1(protein tyrosine phosphatase receptor G gene antisense chain 1,PTPRG-AS1)和 miR-599 表达水平,探讨其与临床病理特征及预后的关系.方法 选取华中科技大学同济医学院附属梨园医院2016年1月至2020年2月收治的106例胃癌患者为研究对象.检测胃癌组织及瘤旁组织中lncRNA PTPRG-AS1和miR-599水平.结果 胃癌组织中lncRNA PTPRG-AS1水平显著高于瘤旁组织,miR-599水平显著低于瘤旁组织(P＜0.05).lncRNA PTPRG-AS1 与 miR-599 水平呈负相关(r=-0.485,P＜0.05).lncRNA PTPRG-AS1、miR-599均与TNM分期、浸润深度、分化程度、淋巴结转移相关(P＜0.05).lncRNA PTPRG-AS1低表达组、miR-599高表达组生存率显著升高(x2=8.206、6.881,P＜0.05).lncRNA PTPRG-AS1、miR-599表达是影响胃癌患者不良预后的危险因素(P＜0.05).结论 胃癌组织中lncRNA PTPRG-AS1和miR-599表达水平与患者临床病理特征及预后密切相关.
Abstract
Objective To analyze the expression levels of long non-coding RNA(lncRNA)protein tyrosine phos-phatase receptor G gene antisense chain 1(PTPRG-AS1)and miR-599 in gastric cancer tissues,and to explore their correlation with clinicopathological characteristics and prognosis.Methods A total of 106 gastric cancer patients admit-ted to Liyuan Hospital of Tongji Medical College of Huazhong University of Science and Technology from Jan.2016 to Feb.2020 were collected as the research subjects.The levels of lncRNA PTPRG-AS1 and miR-599 in gastric cancer tissues and adjacent tissues were detected and compared.Results The expression level of lncRNA PTPRG-AS1 in gas-tric cancer tissue was obviously higher than that in adjacent tissues(P＜0.05),the expression level of miR-599 was ob-viously lower than that in adjacent tissues(P＜0.05).Pearson correlation analysis showed there was an obvious negative correlation between the expression levels of lncRNA PTPRG-AS1 and miR-599 in gastric cancer tissue(r=-0.485,P＜0.05).lncRNA PTPRG-AS1 and miR-599 were both associated with TNM staging,depth of infiltration,degree of dif-ferentiation and lymph node metastasis(P＜0.05).Survival was significantly higher in the lncRNA PTPRG-AS1 low ex-pression group and miR-599 high expression group.LncRNA PTPRG-AS1 and miR-599 expression were risk factors for poor prognosis in gastric cancer patients(P＜0.05).Conclusion The expression levels of lncRNA PTPRG-AS1 and miR-599 in gastric cancer tissues are closely related to the clinical pathological characteristics and prognosis of patients.
关键词
胃癌/长链非编码RNA/蛋白酪氨酸磷酸酶受体G基因反义链1/miR-599/临床病理特征/预后Key words
Gastric cancer/Long non-coding RNA/Protein tyrosine phosphatase receptor G gene antisense chain 1/miR-599/Clinical pathological characteristics/Prognosis引用本文复制引用
基金项目
湖北省卫生健康委科研项目(WJ2021M248)
出版年
2024
NETL
NSTL
万方数据