Clinical characteristics of 478 cases of inflammatory bowel disease in Qinghai region
Objective To study the clinical data and general characteristics of patients with inflammatory bowel dis-eases(IBD)in Qinghai region and improve the diagnosis and treatment level of IBD in primary medical institutions in this region,in order to improve the awareness of dynamic monitoring and follow-up of patients diagnosed with IBD and strengthen standardized treatment.To improve disease prevention awareness of the population in local area.Methods A total of 478 patients with ulcerative colitis(UC)and Crohn's disease(CD),including 366 patients(76.57％)with UC and 112 patients(23.43％)with CD were collected from the Affiliated Hospital of Qinghai University,Qinghai provincial Peo-ple's Hospital,Xining First People's Hospital,Xining Second People's Hospital,Xining Third People's Hospital from Jan.2016 to Jul.2022.Results There was a gender difference in the incidence of the two diseases(222 women with UC and 39 women with CD)(P＜0.05).The mean age of CD was younger than that of UC(P＜0.05).The majority of UC lesions were distant involvement of the whole colon(49.45％),and the severity of disease were mild(55.74％).The ileocolon was predominant(75.00％)and moderate(65.18％)in CD patients.The majority of UC patients were chronic recurrent type(59.29％),and the majority of CD patients were narrow type(65.18％).There was a difference in the incidence of parenteral manifestations between CD(20.77％)and UC(47.32％)(P＜0.05).The incidence of malnutrition in CD patients(45.54％)was higher than that in UC patients(15.58％).The abdominal operation rate(13.39％)and appendectomy rate(26.79％)of CD were significantly higher than those of UC patients(P＜0.05),and the use rate of CD for biologics(34.82％)was also higher than that of UC patients(6.56％)(P＜0.05).Patients with the two diseases were compared in terms of severity.The test results showed that there were statistically significant differences in C-reactive protein,Fe,total protein,albumin,Na+,Ca2+,K+and ESR with the severity(P＜0.05).There was no significant difference in hemoglobin level between mild and moderate severe in UC group(P＞0.05),but signifi-cant difference in CD group(P＜0.05).The severity was different among different nationalities(P＜0.05).Conclusion The incidence of UC is higher than CD in IBD patients in Qinghai,most of them are female.However,the age of diag-nosis of CD is earlier than UC patients,and the disease and severity of CD are more serious,and the number of patients receiving biologics is more common.The severity of the disease is correlated with C-reactive protein,Fe,total protein,albumin,Na+,Ca2+,K+,and the severity of the disease is different among different ethnic groups.
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