Research progress of biliary epithelial cells injury in primary biliary cholangitis
Primary biliary cholangitis(PBC)is a chronic autoimmune disease characterized by bile duct specific in-jury.Inflammation and destruction of interlobular bile duct and septal bile duct occur in the early stage of the disease.Over-expression of miR-506 leads to the damage of bicarbonate umbrella,bile acid toxicity and autoimmune damage to biliary epithelial cells(BEC),the aging of bile duct cells,the decrease of SASP and VDR expression,the change of intestinal microflora and the activation of immune cells all lead to persistent inflammation and fibrosis,which promote the progress of the disease.This paper expounded the research progress of bile duct epithelial cell injury in order to find new therapeutic targets.
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