Efficacy and safety of fecal microbiota transplantation in the treatment of ulcerative colitis:a systematic review and Meta-analysis
Objective To evaluate the efficacy and safety of fecal microbiota transplantation(FMT)for the treat-ment of ulcerative colitis(UC)by Meta-analysis.Methods A computerized search was used to retrieve literature on RCTs of FMT for UC in four databases:PubMed,EmBase,The Cochrane Library and Web of Science,with a timeframe from the beginning of the database construction to Feb.2024.Meta-analysis was performed using RevMan 5.3 software.Results The literature was retrieved from 2 304 articles,and after screening,14 articles were finally included in the Meta-analysis,with a total of 726 patients.The results of the analysis showed that the clinical response rate in the FMT treatment group was significantly higher than that in the control group(MD=2.08,95% CI:1.45-3.00,P<0.0001);the clinical remission rate in the FMT treatment group was significantly higher than that in the control group(MD=2.67,95% CI:1.88-3.79,P<0.00001);and the endoscopic remission rate was significantly higher in the FMT treat-ment group than in the control group(MD=2.19,95% CI:1.42-3.36,P=0.0004);and the incidence of adverse reactions in the FMT treatment group was not statistically different from that in the control group(MD=1.27,95% CI:0.84-1.92,P=0.26).Conclusion The use of FMT for the treatment of UC significantly increased the clinical re-sponse rate,clinical remission rate and endoscopic remission rate of patients,and its safety is not significantly different from that of the control group.However,due to the limited number of included articles,more high-quality RCTs are needed in the future to further confirm the reliability of this Meta-analysis.
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