Microsatellite status of sporadic colorectal adenocarcinoma and its correlation with Fascin-1 expression
Objective To examine the expression of Fascin-1 and mismatch repair proteins(MMRs)in colorectal adenocarcinoma and to explore the role of Fascin-1 in progression of colorectal neoplasm and its correlation with microsa-telite instability(MSI)status.Methods Expressions of four MMRs and Fascin-1 were analyzed from 250 colorectal ad-enocarcinoma and matched non-neoplastic mucosa.MMRs and Fascin-1 expression were compared with several clinico-pathologic parameters of colorectal adenocarcinoma.The correlation of microsatellite instability status and Fascin-1 ex-pression was also analyzed in colorectal adenocarcinoma.Results Fascin-1 protein were barely expressed by the normal colorectal epithelium,but overexpressed in colorectal adenocarcinoma,and the difference between groups were statisti-cally significant(P<0.05).In 250 samples,31 presented MSI-H,32 presented MSI-L and 187 presented MSS,the occurrence rate of MSI-H in cancers was 12.4% (31/250).High expression of Fascin-1 protein correlated significantly with lymph node metastasis and Dukes stage in colorectal adenocarcinoma(P<0.05).MSI-H correlated significantly with tumor differentiation,lymph node metastasis and Dukes stage(P<0.05).The overexpression of Fascin-1 protein positively correlated with the occurrence rate of MSS/MSI-L(rs=0.142,P<0.05).Conclusion Patients with MSS/MSI-L are more likely to appear the highly expression of Fascin-1 than those with MSI-H,which suggested Fascin-1 and MSS/MSI-L may be collaboratively involved in the invasion and metastasis of coloretal adenocarcinoma.Fascin-1 may have the potential to be a newtarget spot on the treatment of MSS/MSI-L colorectal adenocarcinoma.
NETL
NSTL
万方数据
