幽门螺杆菌感染及根除影响肠道微生态紊乱相关机制的研究进展
Research progress of Helicobacter pylori infection and eradication of related mecha-nisms affecting intestinal microecological disorders
高浏璐 1何昱静 2郑英 2李斌 2卢利霞 2李初谊 2张久聪 2于晓辉2
作者信息
- 1. 西北民族大学九四〇临床医学院,甘肃 兰州 730030;中国人民解放军联勤保障部队第九四〇医院消化内科;中国人民解放军联勤保障部队第九四〇医院基础医学实验室,甘肃省干细胞与基因药物实验室
- 2. 中国人民解放军联勤保障部队第九四〇医院消化内科
- 折叠
摘要
幽门螺杆菌(Helicobacter pylori,H.pylori)是引起急慢性胃肠病及胃肠外疾病常见的致病菌,根除 H.pylori对治疗起到关键作用,H.pylori的全球感染率一直居高不下,且近年来由于 H.pylori耐药等机制导致 H.pylori根除效果欠佳,H.pylori感染及其根除过程还会影响肠道微生态的改变,其发生机制异常复杂,是目前医学领域研究的热点.本文对 H.pylori 感染和根除导致肠道微生态紊乱相关机制的最新文献进行归纳、总结,以期为临床抗 H.pylori 治疗过程中如何减少肠道菌群改变和失衡,进而提高H.pylori根除疗效,减少根除治疗引起的不良反应提供一定的理论依据.
Abstract
Helicobacter pylori(H.pylori)is a common pathogenic bacterium that causes acute and chronic gastroin-testinal diseases and parenteral diseases.Eradication of H.pylori plays a key role in the treatment.The global infection rate of H.pylori is always high,and in recent years,the eradication effect of H.pylori is poor due to H.pylori drug resist-ance and other mechanisms.H.pylori infection and its eradication process can also affect the changes of intestinal micro-ecology,and its mechanism is extremely complex,which is a hot topic in the medical field.This paper summarized the latest literature on the mechanism of intestinal microecological disturbance caused by H.pylori infection and eradication,in order to provide certain theoretical basis for how to reduce the change and imbalance of intestinal flora during clinical anti-H.pylori treatment,so as to improve the curative effect of H.pylori eradication and reduce the adverse reactions caused by eradication treatment.
关键词
幽门螺杆菌/肠道微生态/根除疗法Key words
Helicobacter pylori/Intestinal microecology/Eradication therapy引用本文复制引用
基金项目
甘肃省科技计划项目(21JR7RA017)
中央高校基本科研业务费专项资金资助(31920230045)
甘肃省自然科学基金(21JR7RA002)
甘肃省青年科技基金(23JRRA1675)
出版年
2024
NETL
NSTL
万方数据