Research progress on the mechanism of PD-1/PD-L1 inhibitors in the treatment of colorectal cancer
Immunotherapy plays an important role in tumor treatment.It is known that the programmed death receptor-1(PD-1)on the surface of T cells binds to the PD-1 ligand 1(PD-L1)on tumor cells,which can prevent the immune killing effect of T cells on tumor cells and promote immune escape of tumor cells.This paper introduced the problems of PD-1/PD-L1 inhibitors in colorectal cancer treatment,the interaction mechanism of signaling pathways such as PI3K/AKT,JAK/STAT,MAPK and NF-κB with PD-1/PD-L1 in colorectal cancer,and further discussed the thera-peutic studies of PD-1/PD-L1 inhibitors with gut microbes,chemotherapy,radiotherapy,targeted and natural com-pounds.
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