Advances in molecular characteristics of the serrated pathway in colorectal cancer
Colorectal cancer(CRC)is one of the leading causes of cancers death worldwide.In the past decade,in addition to the traditional adenomato-cancer pathway,research has identified another multi-step mechanism of carcino-genesis,the ″serrated pathway″,from which approximately 20% -30% of CRC originate.The high heterogeneity of serra-ted lesions makes diagnosis and pathological interpretation difficult.Therefore,in order to better classify and manage CRC,new biomarkers are needed to distinguish sessile serrated adenomas/polyps(SSA/Ps)from hyperplastic polyps(HPs)with higher sensitivity and specificity.So far,several molecular alterations have been associated with serrated CRC.In addition,the gut microbiota is emerging as a new biomarker for the serrated pathway.This article reviewed the recent research advances in genetic and epigenetic changes associated with serrated CRC,as well as microbiota charac-teristics and their clinical significance.
Serrated lesionsBRAF and KRAS mutationsCIMPGut microbiotaBiomarkers
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