外泌体参与结直肠癌肝转移发病机制的研究进展
Research progress of exosomes participated in liver metastasis pathogenesis of color-ectal cancer
陈儒德 1王强 1陈绍华 1魏博文 1陈良彬 1刘建 1赵继辉 1江宗兴1
作者信息
- 1. 成都市新都区人民医院肝胆胰脾外科,四川 成都 610083
- 折叠
摘要
结直肠癌是全世界最常见的第三大癌症,60%的患者在未经过有效治疗的情况下会发生肝转移.其发病率和死亡率均很高.尽管诊断和治疗技术取得了很大进展,但结直肠癌肝转移(colorectal cancer liver metastasis,CRLM)患者的生存率仍然很低.外泌体作为细胞间通讯中的重要介质被广泛研究,在 CRLM 发病过程中的每一步都有非常重要的影响.本文归纳了不同来源、不同内含物外泌体通过包括:促进上皮-间充质转化(epithelial-mesenchymal transition,EMT)、调节细胞外基质(extracellular matrix,ECM)、增加血管生成和血管通透性、促进转移前生态位(pre-metastatic niche,PMN)形成、参与免疫抑制等途径来影响 CRLM 发病的机制,以期为未来 CRLM 提供潜在诊断及治疗靶点.
Abstract
Colorectal cancer is the third most common cancer worldwide,with liver metastasis occurring in 60% of patients without effective treatment.Morbidity and mortality are high.Despite great advances in diagnostic and therapeu-tic techniques,survival rates for patients with colorectal cancer liver metastasis(CRML)remain low.Exosomes have been widely studied as important mediators in cell-to-cell communication and have a very important impact on colorectal cancer at every step of the liver metastasis process.In this article,we summarized the mechanisms of different endophyll exosomes from different sources to influence the pathogenesis of CRML by promoting epithelial-mesenchymal transition(EMT),regulating the extracellular matrix(ECM),increasing angiogenesis and vascular permeability,promoting pre-metastatic niche(PMN)formation,and participating in immunosuppression,in order to provide potential diagnostic and therapeutic targets for future CRLM.
关键词
结直肠癌肝转移/外泌体/肿瘤微环境/上皮-间充质转化/细胞外基质/转移前生态位/肿瘤相关巨噬细胞Key words
Colorectal cancer liver metastasis/Exosome/Tumor microenvironment/Epithelial-mesenchymal transi-tion/Extracellular matrix/Pre-metastatic niche/Tumor associated macrophages引用本文复制引用
出版年
2024
NETL
NSTL
万方数据