生活方式、肠道菌群与非酒精性脂肪性肝病的关系
Relationship between lifestyle,intestinal flora and non-alcoholic fatty liver disease
陈格 1孙旭彤 1孔玲玲 1王梓璇 2王美娇 2赵红1
作者信息
- 1. 康复大学青岛中心医院(青岛市中心医疗集团)消化内一科,山东 青岛 266042
- 2. 康复大学青岛中心医院(青岛市中心医疗集团)消化内一科,山东 青岛 266042;青岛大学青岛医学院
- 折叠
摘要
非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)已成为一个全球性的健康问题,其发病机制至今尚未完全阐明,诸多因素均被发现与该疾病密切相关.肠道菌群是人体最大的微生态系统,可通过多种作用轴及代谢产物参与疾病的发展过程;生活方式包括衣食住行等多个方面,其中改变饮食及运动等方式可影响多种疾病的控制或治疗;而生活方式改变又被认为是调节肠道菌群组成的主要驱动力之一.随着更多证据的出现,我们发现生活方式、肠道菌群与 NAFLD 之间关系密切,三者之间的相互关系或可成为治疗 NAFLD 的新靶标.
Abstract
Non-alcoholic fatty liver disease(NAFLD)has become a global health problem,its pathogenesis has not been fully elucidated,and many factors have been found to be closely related to the disease.Intestinal flora is the largest microecosystem in human body,which can participate in the development of diseases through various axes and metabo-lites.Lifestyle includes many aspects such as clothing,food,housing and transportation,among which changing diet and exercise can affect the control or treatment of a variety of diseases.Lifestyle changes are considered to be one of the main driving forces regulating the composition of intestinal flora.With the emergence of more evidence,we found that li-festyle,intestinal flora and NAFLD are closely related,and the association between the three may become a new target for the treatment of NAFLD.
关键词
非酒精性脂肪性肝病/肠道菌群/生活方式/饮食/运动Key words
Non-alcoholic fatty liver disease/Intestinal flora/Lifestyle/Diet/Exercise引用本文复制引用
基金项目
国家自然科学基金(31800660)
青岛市医药卫生科研计划项目(2021-WJZD098)
青岛市医疗卫生重点学科建设项目()
出版年
2024
NETL
NSTL
万方数据