摘要
铜是人体必需的微量元素,在各种生理过程中起着至关重要的作用.然而,过量的铜积累会导致氧化应激、DNA 损伤,并最终导致疾病的发生.肝脏是铜储存的重要器官,血清铜水平变化对肝脏的生理功能具有直接影响.近年来,血清铜水平与肝脏疾病的联系引起了极大的关注.本文综述了铜的生理代谢过程,铜失衡通过脂质代谢异常、氧化应激、免疫抑制、血管侵袭、阻碍药物吸收等途径发生肝脏毒性作用,而靶向铜治疗可能是治疗终末期肝病的潜在方法.
Abstract
Copper is a critical trace element that performs essential functions in various physiological processes.However,excessive copper accumulation can result in oxidative stress,DNA damage,and ultimately tumorigenesis.The liver,as a crucial organ for copper storage,is significantly impacted by changes in serum copper levels,which directly affect its physiological functions.The link between serum copper levels and liver disease has attracted considerable at-tention in recent years.This paper reviewed the physiological metabolic processes of copper,the hepatotoxic effects of copper imbalance occurring through abnormal lipid metabolism,oxidative stress,immunosuppression,vascular invasion,and blockage of drug absorption,and the potential that targeted copper therapy may be a potential approach for the treat-ment of end-stage liver disease.
基金项目
研究生科研创新能力提升计划(2022KYCX010)
陕西省中医药管理局中医药防治消化道癌前病变重点研究室项目(陕中医药发[2019]9号)
陕西中医药大学附属医院科研课题(2020XZ001)
NETL
NSTL
万方数据