Copper is a critical trace element that performs essential functions in various physiological processes.However,excessive copper accumulation can result in oxidative stress,DNA damage,and ultimately tumorigenesis.The liver,as a crucial organ for copper storage,is significantly impacted by changes in serum copper levels,which directly affect its physiological functions.The link between serum copper levels and liver disease has attracted considerable at-tention in recent years.This paper reviewed the physiological metabolic processes of copper,the hepatotoxic effects of copper imbalance occurring through abnormal lipid metabolism,oxidative stress,immunosuppression,vascular invasion,and blockage of drug absorption,and the potential that targeted copper therapy may be a potential approach for the treat-ment of end-stage liver disease.
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