Research progress in the treatment of refractory ascites in cirrhosis
Ascites is one of the common complications of decompensated cirrhosis,and the treatment basis includes salt restriction and diuresis.About 10%of patients with ascites will be ineffective or intolerable to conventional large-dose diuretic therapy and develop into refractory ascites.Large volume paracentesis with albumin infusion and transjugu-lar intrahepatic portosystemic shunt have become the first-line and the second-line treatment methods.Modalities such as Rifaximin,Midodrine,Tolvaptan and other drugs have also been proved to be useful for the relief of refractory ascites.In recent years,the exploration of the safety and efficacy of the treatment of refractory ascites has gradually increased,which may provide more options for the treatment of patients with refractory ascites in the future.