Macroamylasemia is a rare disease marked by elevated blood amylase without specific symptoms and signs.Macroamylase is a macromolecular circulating complex of amylase and immunoglobulin that cannot be filtered through the kidney.Two cases of macroamylasemia were reported,with elevated serum amylase,normal renal function,normal urine amylase,amylase-creatinine clearance rate of less than 1％,and polyethylene glycol(PEG)precipitation rate of more than 73％.Pancreatic and parotid gland diseases and other related diseases were excluded.Macroamylasemia is not only associated with autoimmune diseases,malignant tumors and other diseases,but also can occur in healthy people.
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