小剂量阿奇霉素治疗慢性中度持续期哮喘患儿的临床效果
Clinical effect of low-dose Azithromycin in the treatment of children with chronic moderate persistent asthma
农常亮 1黄楚洪 2韦未红 1廖景贵 1孙瑀泽 1潘美琴1
作者信息
- 1. 南宁市第二人民医院儿科,广西南宁 530031
- 2. 南宁市第二人民医院超声医学科,广西南宁 530031
- 折叠
摘要
目的 探讨小剂量阿奇霉素治疗慢性中度持续期哮喘患儿的临床效果.方法 选取 2022 年1月至 2023 年1月于南宁市第二人民医院治疗的 50 例慢性中度持续期哮喘患儿为研究对象,按照随机数字表法分为对照组与观察组,每组各 25 例.对照组采用布地奈德福莫特罗粉吸入剂治疗,观察组在对照组基础上采用小剂量阿奇霉素治疗.比较两组的肺功能指标、炎症因子水平、治疗总有效率、不良反应总发生率.结果 治疗后,观察组第1秒用力呼气容积(FEV1)/用力肺活量、FEV1 占预计值百分比高于对照组,白细胞介素(IL)-18、IL-6、超敏C反应蛋白水平低于对照组(P<0.05);观察组治疗总有效率高于对照组(P<0.05),不良反应总发生率低于对照组(P<0.05).结论 小剂量阿奇霉素治疗慢性中度持续期哮喘患儿的临床效果显著,能够改善肺功能,减轻炎症反应,降低不良反应发生率,值得推广.
Abstract
Objective To investigate the clinical effect of low-dose Azithromycin in the treatment of children with chronic moderate persistent asthma.Methods A total of 50 children with chronic moderate persistent asthma in the Second Nanning People's Hospital from January 2022 to January 2023 were selected and divided into control group and observation group by the random number table method,with 25 cases in each group.The control group was treated with Budesonide Formoterol Powder Inhalation,while the observation group was treated with low-dose Azithromycin on the basis of control group.The pulmonary function index,inflammatory factor level,total effective rate and total incidence of adverse reactions were compared between the two groups.Results The the forced expiratory volume in one second(FEV1)/forced vital capacity and FEV1%/predicted value ratio in the observation group were higher than those in the control group(P<0.05),the levels of interleukin(IL)-18,IL-6 and hypersensitive C-reactive protein in the observation group were lower than those in the control group(P<0.05).The total effective rate in the observation group was higher than that in the control group,and the total incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion Low-dose Azithromycin treating children with chronic moderate persistent asthma has significant clinical effect,which can improve lung function,reduce inflammation reactions,decrease the incidence of adverse reactions,and is worth promoting.
关键词
慢性中度持续期哮喘/儿童/阿奇霉素/肺功能/炎症因子Key words
Chronic moderate persistent asthma/Children/Azithromycin/Lung function/Inflammatory factor引用本文复制引用
基金项目
广西卫生健康委自筹经费科研课题(Z20210080)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据