高剂量维生素D补充剂对绝经后骨质疏松症患者骨代谢标志物、骨密度的影响
Effect of high-dose vitamin D supplement on bone metabolic markers and bone mineral density in postmenopausal patients with osteoporosis
刘彩霞1
作者信息
- 1. 山东省淄博市临淄区妇幼保健院 (齐都医院)妇科,山东淄博 255400
- 折叠
摘要
目的 探究高剂量维生素D补充剂对绝经后骨质疏松症患者骨代谢标志物、骨密度的影响.方法 选取 2021年 2 月至 2022 年 2 月淄博市临淄区妇幼保健院(齐都医院)妇科治疗的120 例绝经后骨质疏松症患者作为研究对象,按照随机数字表法分为对照组(60 例)和观察组(60 例).对照组采用口服维生素D治疗,观察组在对照组基础上注射维生素D针剂治疗,比较两组骨代谢标志物和骨密度.结果 观察组治疗 3、6、12 个月后血清Ⅰ型胶原羧基端肽β特殊序列、Ⅰ型前胶原氨基端肽水平均低于对照组(P<0.05);观察组各部位骨密度均高于对照组(P<0.05).结论 绝经后骨质疏松症患者补充高剂量维生素D可有效减少体内的骨量流失,改善骨代谢水平,提高骨密度.
Abstract
Objective To explore the effect of high-dose vitamin D supplement on bone metabolic markers and bone mineral density in postmenopausal patients with osteoporosis.Methods A total of 120 postmenopausal patients with osteoporosis admitted to the Department of Gynecology,Linzi District Maternal and Child Health Hospital of Zibo(Qidu Hospital)from February 2021 to February 2022 were selected as the study objects.All the patients were divided into the control group(60 cases)and the observation group(60 cases)according to the random number table method.The control group was treated with oral vitamin D,and the observation group was treated with vitamin D injection on the basis of the control group.The bone metabolism markers and bone mineral density were compared between the two groups.Results The levels of β-isomer of C-terminal telopeptide of type Ⅰ collagen and type Ⅰ procollagen N-terminal propeptide after 3,6 and 12 months of treatment in the observation group were lower than those in the control group(P<0.05).The bone density of various parts in the observation group was higher than that in the control group(P<0.05).Conclusion For postmenopausal patients with osteoporosis,supplementing high-dose of vitamin D can effectively reduce bone mass loss in the body,improve bone metabolism levels and increase bone mineral density.
关键词
维生素D补充剂/绝经期/骨质疏松症/骨代谢标志物/骨密度Key words
Vitamin D supplement/Menopause/Osteoporosis/Bone metabolic marker/Bone mineral density引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据