摘要
目的 探讨重度新生儿黄疸的相关影响因素,为防控重度新生儿高胆红素血症、急性胆红素脑病提供临床依据.方法 收集 2020 年7月至 2023年 6 月柳州市中医医院新生儿科的313例高胆红素血症患儿的临床资料进行回顾性分析,轻中度高胆红素血症 264例为A组,重度高胆红素血症49 例为B组,分析重度新生儿黄疸的相关影响因素.结果 单因素分析结果显示,重度新生儿黄疸与剖宫产、小于胎龄儿、新生儿ABO溶血病、新生儿葡萄糖-6-磷酸脱氢酶缺乏症、新生儿感染性肺炎、新生儿头皮血肿、母亲妊娠高血压、母亲妊娠糖尿病、母亲肥胖、母亲贫血、母亲胆汁淤积症、母亲甲状腺功能异常有关(P<0.05).多因素分析结果显示,小于胎龄儿、新生儿ABO溶血病、新生儿头皮血肿、母亲妊娠高血压、母亲妊娠糖尿病、母亲甲状腺功能异常是重度高胆红素血症的独立危险因素(P<0.05).结论 重度新生儿黄疸的相关影响因素较多,产、儿科医生应熟识每一位孕妇的围产期高危因素,早发现、早诊断、早干预,做好宣教,防止或减少重度新生儿黄疸的发生.
Abstract
Objective To explore the related influencing factors of severe neonatal jaundice,and provide clinical basis for the prevention and control of severe neonatal hyperbilirubinemia and acute bilirubin encephalopathy.Methods Clinical data of 313 children with hyperbilirubinemia in the Department of Neonatology,Liuzhou Traditional Chinese Medical Hospital from July 2020 to June 2023 were retrospectively analyzed,264 cases of mild or moderate hyperbilirubinemia were in group A,and 49 cases of severe hyperbilirubinemia were in group B.The related influencing factors of severe neonatal jaundice were analyzed.Results The univariate analysis showed that severe neonatal jaundice were associated with cesarean section,small for gestational age infant,ABO hemolytic disease of the newborn,glucose-6-phoshate dehydrogenase deficiency,neonatal infectious pneumonia,neonatal scalp hematoma,maternal gestational hypertension,maternal gestational diabetes mellitus,maternal obesity,maternal anemia,maternal cholestasis,and maternal abnormal thyroid function(P<0.05).The multivariate analysis showed that small for gestational age infant,ABO hemolytic disease of the newborn,neonatal scalp hematoma,maternal gestational hypertension,maternal gestational diabetes mellitus,and maternal abnormal thyroid function were the independent risk factors for severe hyperbilirubinemia(P<0.05).Conclusion There are many factors related to severe neonatal jaundice,and the obstetricians and pediatricians should be familiar with the high-risk factors of each pregnant woman during the perinatal period.Early detection,diagnosis,intervention and education should be carried out to prevent or reduce the occurrence of severe neonatal jaundice.
基金项目
广西壮族自治区中医药管理局自筹经费科研课题(GZZC2020426)
国家科技期刊平台
NSTL
维普
万方数据