216例重症肺炎患儿肺泡灌洗液病原微生物分布特点分析
Analysis of pathogenic microorganism distribution characteristics in bronchoalveolar lavage fluid of 216 children with severe pneumonia
唐盐林 1黄树稳 1颜云盈1
作者信息
- 1. 南宁市妇幼保健院儿科,广西南宁 530000
- 折叠
摘要
目的 分析重症肺炎患儿肺泡灌洗液病原微生物分布特点.方法 选取 2021年 6 月至 2022 年6 月南宁市妇幼保健院儿科收治的 216 例重症肺炎患儿,收集肺泡灌洗液进行多重核酸检测,分析病原微生物分布特点.结果 216 例患儿中,检出病原微生物阳性 210 例,阳性率为 97.22%.患儿以混合感染为主,且多为细菌、病毒混合感染.共检出病原微生物458 株.细菌占比40.61%,其中革兰氏阳性菌占比49.46%,以肺炎链球菌为主;革兰氏阴性菌占比 50.54%,以流感嗜血杆菌为主.病毒占比44.76%,以呼吸道合胞病毒和巨细胞病毒为主.真菌占比8.73%,以耶氏肺孢子菌为主.肺炎支原体占比4.59%,肺炎衣原体占比1.31%.细菌感染主要发生于学龄前期儿童,真菌感染主要发生于婴儿群体.细菌感染多发于春季,病毒感染多发于秋季.结论 重症肺炎患儿肺泡灌洗液病原检出阳性率较高,病原微生物中细菌感染以肺炎链球菌为主,病毒感染以呼吸道合胞病毒为主,多为混合感染.病原微生物分布存在年龄、季节差异.
Abstract
Objective To analyze the pathogenic microorganism distribution characteristics in bronchoalveolar lavage fluid of 216 children with severe pneumonia.Methods A total of 216 children with severe pneumonia admitted to the Department of Pediatrics of Nanning Maternity and Child Health Hospital from June 2021 to June 2022 were selected,and bronchoalveolar lavage fluid was collected for multiple nucleic acid detection to analyze the pathogenic microorganism distribution characteristics.Results Among 216 children,210 were positive for pathogenic microorganisms,with a positive rate of 97.22%.The majority of the children were mixed infections,and most of them were mixed infections of bacteria and viruses.A total of 458 pathogenic microorganisms were detected.Bacteria accounted for 40.61%,among which Gram positive bacteria accounted for 49.46%,mainly Streptococcus pneumoniae.The proportion of Gram negative bacteria was 50.54%,mainly Haemophilus influenzae.Viruses accounted for 44.76%,mainly respiratory syncytial virus and cytomegalovirus.Fungi accounted for 8.73%,mainly Pneumocystis jirovecii.Mycoplasma pneumoniae accounted for 4.59%and Chlamydia pneumoniae accounted for 1.31%.Bacterial infection mainly occurred in early school age children,and fungal infection mainly occurred in infants.Bacterial infection was more common in spring,and viral infection was more common in autumn.Conclusion The positive rate of pathogen detection in bronchoalveolar lavage fluid of children with severe pneumonia is higher.The main bacterial infection is Streptococcus pneumoniae,and the main viral infection is respiratory syncytial virus,mostly mixed infection.There are age and season differences in the distribution of pathogenic microorganisms.
关键词
重症肺炎/肺泡灌洗液/病原微生物/分布特点Key words
Severe pneumonia/Bronchoalveolar lavage fluid/Pathogenic microorganism/Distribution characteristic引用本文复制引用
基金项目
广西壮族自治区卫生健康委员会自筹经费科研课题(Z20211403)
出版年
2024
国家科技期刊平台
NSTL
万方数据