血尿素氮在妊娠糖尿病合并慢性高血压孕产妇子痫前期伴发与新生儿出生体重间的中介效应分析
Analysis of the mediating effect of blood urea nitrogen on preeclampsia in pregnant women with gestational diabetes mellitus complicated with chronic hypertension and neonatal birth weight
王晓敏 1李忠良 2田寅 3韩颖 1于大芳1
作者信息
- 1. 山东第一医科大学附属济南妇幼保健院护理部,山东济南 250000
- 2. 山东第一医科大学附属济南妇幼保健院妇女保健所,山东济南 250000
- 3. 山东第一医科大学附属济南妇幼保健院门诊部,山东济南 250000
- 折叠
摘要
目的 分析血尿素氮(BUN)在妊娠糖尿病(GDM)合并慢性高血压(CHT)孕产妇子痫前期(PE)伴发与新生儿出生体重(NBW)间的中介效应.方法 选取 2017 年1月至 2022 年12 月于山东第一医科大学附属济南妇幼保健院进行产检并分娩的 246 例GDM合并CHT孕产妇进行回顾性分析,根据是否伴发PE分为A组(未伴发,163 例)和B组(伴发,83 例).收集并分析两组临床资料.结果 B组NBW低于A组,BUN水平高于A组(P<0.05).PE的伴发与NBW呈负相关(P<0.001),BUN水平与NBW呈负相关(P<0.001).BUN水平在PE的伴发与NBW之间发挥部分中介效应,中介效应值占总效应值的 22.01%.结论 GDM合并CHT伴发PE孕妇相较于未伴发PE孕妇,NBW更低,BUN水平更高,且BUN水平在PE的伴发与NBW之间发挥部分中介效应.因此对于GDM合并CHT孕妇,应密切观察其病情变化,避免伴发PE,同时重点关注BUN指标的变化.
Abstract
Objective To analyze the mediating effect of blood urea nitrogen(BUN)on preeclampsia(PE)in pregnant women with gestational diabetes mellitus(GDM)complicated with chronic hypertension(CHT)and neonatal birth weight(NBW).Methods A retrospective analysis was performed on 246 pregnant women with GDM complicated with CHT who were given birth in Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University from January 2017 to December 2022.They were divided into group A(without PE,163 cases)and group B(with PE,83 cases)according to whether they were accompanied by PE.Clinical data of the two groups were collected and analyzed.Results The NBW of group B was lower than that of group A,and the BUN level of group B was higher than that of group A(P<0.05).The concomitant of PE was negatively correlated with NBW(P<0.001),and BUN level was negatively correlated with NBW(P<0.001).BUN level played a partial mediating effect between PE concomitant and NBW,and the mediating effect value accounted for 22.01%of the total effect value.Conclusion Pregnant women with GDM and CHT accompanied by PE have lower NBW and higher BUN levels than pregnant women without PE,and BUN levels play a partial mediating effect between PE and NBW.Therefore,for pregnant women with GDM complicated with CHT,the changes of their disease should be closely observed to avoid concomitant of PE,and the changes of BUN index should be focused on.
关键词
妊娠糖尿病/妊娠合并慢性高血压/子痫前期/尿素氮/新生儿出生体重Key words
Gestational diabetes mellitus/Pregnancy with chronic hypertension/Preeclampsia/Blood urea nitrogen/Neonatal birth weight引用本文复制引用
基金项目
济南市卫生健康委员会科技计划项目(2023-2-106)
出版年
2024
国家科技期刊平台
NSTL
万方数据