Objective To investigate the clinical effect of blue light combined with low-dose Vitamin D in the treatment of neonatal jaundice.Methods From November 2019 to November 2022,68 neonates with jaundice who were treated in the Department of Neonatology of People's Hospital of Pingyi County were selected and divided into the control group(n=34)and the observation group(n=34)according to the random number table method.The control group was treated with blue light,and the observation group was treated with blue light combined with low-dose Vitamin D.The jaundice index,serum bilirubin levels and the occurrence of adverse reactions were compared between the two groups.Results After 2 and 5 days of treatment,the jaundice index of the observation group was lower than that of the control group(P<0.05).After treatment,the levels of direct bilirubin and total bilirubin in the observation group were lower than those in the control group(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion Blue light combined with low-dose Vitamin D in the treatment of neonatal jaundice can reduce jaundice index,serum bilirubin levels and the occurrence of adverse reactions,which can be widely used in clinical practice.