Objective To investigate the clinical effect of modified Sangju Decoction combined with Zhisou Powder in the treatment of Mycoplasma pneumoniae infection in children.Methods A total of 92 children with Mycoplasma pneumoniae infection admitted to Jiyang District Hospital of Traditional Chinese Medicine of Jinan City from August 2021 to July 2023 were selected and divided into the control group(46 cases)and the observation group(46 cases)according to the random number table method.The control group received conventional western medicine treatment,and the observation group received modified Sangju Decoction combined with Zhisou Powder on the basis of the control group.The disappearance time of clinical symptoms and signs,clinical efficacy and total incidence of adverse reactions were compared between the two groups.Results The disappearance time of fever,cough and pulmonary rales in the observation group was shorter than that in the control group(P<0.05).The total effective rate of the observation group was higher than that of the control group(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion Modified Sangju Decoction combined with Zhisou Powder in the treatment of Mycoplasma pneumoniae infection in children,can improve clinical symptoms and signs,and has safety,which is worthy of clinical application.