妇儿健康导刊2024，Vol.3Issue(7) ：17-20,61.

长链非编码RNA与多囊卵巢综合征患者卵子发育关系的研究进展

Research progress on the relationship between long non-coding RNA and oocyte development in patients with polycystic ovary syndrom

王蕾童
妇儿健康导刊2024，Vol.3Issue(7) ：17-20,61.
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  • 维普
  • 万方数据

长链非编码RNA与多囊卵巢综合征患者卵子发育关系的研究进展

Research progress on the relationship between long non-coding RNA and oocyte development in patients with polycystic ovary syndrom

王蕾童1
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作者信息

  • 1. 沈阳菁华医院辅助生殖实验室,辽宁沈阳 110000
  • 折叠

摘要

多囊卵巢综合征(PCOS)是育龄期女性最常见的内分泌疾病之一,患病率为 5%～10%.PCOS可能是一种多基因疾病,其病因较复杂,主要受到表观遗传和环境因素的影响.长链非编码RNA(lncRNA)在PCOS卵泡发育等过程中发挥重要作用,在PCOS患者的卵泡液及颗粒细胞中均发现异常表达,其与细胞增殖和凋亡、细胞核成熟及卵泡发育有关.本文主要综述lncRNA与PCOS患者卵子发育的关系.

Abstract

Polycystic ovary syndrome(PCOS)is one of the most common endocrine disorders in women of reproductive age,with a prevalence of 5%to 10%.PCOS may be a polygenic disease,the etiology of PCOS is complex and is mainly influenced by epigenetic and environmental factors.Long non-coding RNA(lncRNA)plays an important role in the development of follicles in PCOS.Abnormal expression of lncRNA is found in follicular fluid and granulosa cells of PCOS patients,and it is related to cell proliferation and apoptosis,nuclear maturation and follicle development.This paper mainly reviewed the relationship between lncRNA and oocyte development in patients with PCOS.

关键词

长链非编码RNA/多囊卵巢综合征/颗粒细胞/卵母细胞/综述

Key words

Long non-coding RNA/Polycystic ovary syndrome/Granulosa cell/Oocyte/Review

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基金项目

辽宁省沈阳市卫生健康委科研项目(2023110)

出版年

2024
妇儿健康导刊
婚姻与家庭杂志社

妇儿健康导刊

ISSN：2097-115X
参考文献量37
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