基于肠道菌群探讨中药治疗卵巢癌的研究进展
Research progress of traditional Chinese medicine in the treatment of ovarian cancer based on intestinal flora
陈雅琳 1陈捷 2章斌斌2
作者信息
- 1. 福建中医药大学第一临床医学院,福建福州 350122
- 2. 福建中医药大学附属人民医院妇科,福建福州 350004
- 折叠
摘要
卵巢癌是常见的妇科恶性肿瘤之一,可发生于任何年龄,致死率高.近年来,肠道菌群成为研究热点,肠道菌群与人体各系统疾病存在一定的联系.肠道是人体重要的免疫器官,肠道菌群失衡将引起各种慢性炎症、免疫失调及异常生理过程,从而改变基因表达和微环境稳态,引发癌症.目前中医多联合化疗手段治疗卵巢癌.本文对中药调节肠道菌群影响卵巢癌发展的机制进行综述,为临床中医治疗卵巢癌提供依据.
Abstract
Ovarian cancer is one of the most common gynecological malignancies,which can occur at any age and has a high mortality rate.In recent years,intestinal flora has become a research hotspot,and intestinal flora has a certain relationship with various system diseases of the human body.The gut is an important immune organ of the human body.The imbalance of intestinal flora will cause a variety of chronic inflammation,immune disorders and abnormal physiological processes,which will change gene expression and microenvironment homeostasis,and lead to cancer.At present,traditional Chinese medicine combined with chemotherapy is used to treat ovarian cancer.This article reviews the mechanism of traditional Chinese medicine regulating intestinal flora and affecting the development of ovarian cancer,so as to provide a basis for the clinical treatment of ovarian cancer with traditional Chinese medicine.
关键词
中药/肠道菌群/卵巢癌/炎症/免疫/雌激素Key words
Traditional Chinese medicine/Intestinal flora/Ovarian cancer/Inflammation/Immunity/Estrogen引用本文复制引用
基金项目
福建中医药大学校管课题临床专项(XB2023006)
出版年
2024
国家科技期刊平台
NSTL
万方数据