匹多莫德治疗小儿呼吸系统反复感染的临床效果
Clinical effect of Pidotimod in the treatment of children with recurrent respiratory system infection
李德国 1张磊1
作者信息
- 1. 山东省安丘市人民医院儿科,山东安丘 262100
- 折叠
摘要
目的 探讨匹多莫德治疗小儿呼吸系统反复感染的临床效果.方法 选取 2022 年1月至12 月安丘市人民医院治疗的 96 例呼吸系统反复感染患儿作为研究对象,按照随机数字表法分为对照组和观察组,每组各48 例.对照组采用美洛西林钠联合布地奈德治疗,观察组在对照组基础上采用匹多莫德治疗.比较两组炎症因子水平、免疫球蛋白水平、临床症状消失时间、肺功能、临床疗效、不良反应发生情况和再次感染情况.结果 治疗后,观察组γ干扰素、白细胞介素-2 水平高于对照组,肿瘤坏死因子-α、白细胞介素-4水平低于对照组(P<0.05);观察组各项临床症状消失时间均短于对照组(P<0.05);观察组免疫球蛋白A、免疫球蛋白G、免疫球蛋白M水平均高于对照组(P<0.05);观察组第1秒用力呼气容积、用力肺活量、最高呼气流速变异率、一秒率水平均高于对照组(P<0.05);观察组临床总有效率高于对照组(P<0.05);观察组不良反应总发生率低于对照组(P<0.05);观察组再次感染次数少于对照组,再感染持续时间短于对照组(P<0.05).结论 匹多莫德治疗小儿呼吸系统反复感染的临床效果较好,值得推广.
Abstract
Objective To explore the clinical effect of Pidotimod in the treatment of children with recurrent respiratory system infection.Methods A total of 96 children with recurrent respiratory system infection admitted to Anqiu People's Hospital from January to December 2022 were selected as the study objects.All the children were divided into the control group and the observation group by the random number table method,with 48 cases in each group.The control group was treated with Melocillin Sodium combined with Budesonide,while the observation group was treated with Pidotimod on the basis of the control group.The levels of inflammatory factors and immunoglobulin,disappearance time of clinical symptoms,pulmonary function,clinical efficacy,incidence of adverse reactions and reinfection of the two groups were compared.Results After treatment,the levels of interferon-γ and interleukin-2 in the observation group were higher than those in the control group,the levels of tumor necrosis factor-α and interleukin-4 were lower than those in the control group(P<0.05).The disappearance time of clinical symptoms in the observation group was shorter than that in the control group(P<0.05).The levels of immunoglobulin A,immunoglobulin G and immunoglobulin M in the observation group were higher than those in the control group(P<0.05).The levels of forced expiratory volume in one second,forced vital capacity,peak expiratory flow rate and forced expiratory volume in one second/forced vital capacity in the observation group were higher than those in the control group(P<0.05).The total clinical effective rate of the observation group was higher than that of the control group(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).The number of reinfection in the observation group was fewer than that in the control group,and the duration of reinfection was shorter than that in the control group(P<0.05).Conclusion The clinical effect of Pidomod in the treatment of children with recurrent respiratory system infection is better and worthy of promotion.
关键词
呼吸系统反复感染/匹多莫德/炎症因子/肺功能Key words
Recurrent respiratory system infection/Pidotimod/Inflammatory factor/Pulmonary function引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据