丙酸氟替卡松吸入气雾剂日均小剂量雾化与间断雾化治疗小儿哮喘的效果比较
Comparison of the effect of daily low-dose nebulization and intermittent nebulization of Fluticasone Propionate Inhalation Aerosol in the treat-ment of children with asthma
于俊平1
作者信息
- 1. 山东省无棣县中医院儿科,山东无棣 251900
- 折叠
摘要
目的 比较丙酸氟替卡松吸入气雾剂日均小剂量雾化与间断雾化治疗小儿哮喘的效果.方法 选取 2021年 9 月至 2023 年 9 月无棣县中医院治疗的 86 例哮喘患儿作为研究对象,按照随机数字表法分为常规组(n=43)和试验组(n=43).常规组采用丙酸氟替卡松吸入气雾剂日均小剂量雾化治疗,试验组采用丙酸氟替卡松吸入气雾剂间断雾化治疗,比较两组临床疗效、肺功能、哮喘评分、免疫球蛋白E和嗜酸性粒细胞水平.结果 治疗后,试验组治疗总有效率高于常规组(P<0.05);试验组用力肺活量、一秒率水平均高于常规组(P<0.05);试验组哮喘日间和夜间评分均低于常规组(P<0.05);试验组免疫球蛋白E和嗜酸性粒细胞水平均低于常规组(P<0.05).结论 丙酸氟替卡松吸入气雾剂间断雾化治疗小儿哮喘,可降低免疫球蛋白和嗜酸性粒细胞水平,改善肺功能和哮喘症状,有效提高临床疗效.
Abstract
Objective To compare the effect of daily low-dose nebulization and intermittent nebulization of Fluticasone Propionate Inhalation Aerosol in the treatment of children with asthma.Methods A total of 86 children with asthma admitted to Wudi County Hospital of Traditional Chinese Medicine from September 2021 to September 2023 were selected as the study objects.All the children were divided into the conventional group(n=43)and the experimental group(n=43)using the random number table method.The conventional group was treated with daily low-dose nebulization of Fluticasone Propionate Inhalation Aerosol,and the experimental group was treated with intermittent nebulization of Fluticasone Propionate Inhalation Aerosol.The clinical efficacy,lung function,asthma score,the levels of immunoglobulin E and eosinophil were compared between the two groups.Results After treatment,the total effective rate of treatment in the experimental group was higher than that in the conventional group(P<0.05).The levels of forced vital capacity and forced expiratory volume in one second/forced vital capacity in the experimental group were higher than those in the conventional group(P<0.05).The asthma scores during the daytime and nighttime in the experimental group were lower than those in the conventional group(P<0.05).The levels of immunoglobulin E and eosinophilic in the experimental group were lower than those in the conventional group(P<0.05).Conclusion The treatment of intermittent nebulization of Fluticasone Propionate Inhalation Aerosol in children with asthma can reduce the levels of immunoglobulin and eosinophil,improve lung function and asthma symptoms,and effectively enhance clinical efficacy.
关键词
丙酸氟替卡松吸入气雾剂/小儿哮喘/间断雾化Key words
Fluticasone Propionate Inhalation Aerosol/Children with asthma/Intermittent nebulization引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据