来曲唑低剂量序贯递增与恒量治疗多囊卵巢综合征不孕症的临床效果比较
Comparison of clinical effects of low dose sequential increase and constant dose of Letrozole in the treatment of infertility with polycystic ovary syndrome
李鸿婧 1罗云辽2
作者信息
- 1. 贵州省人民医院生殖医学科,贵州贵阳 550002
- 2. 贵州省赫章县人民医院妇科,贵州赫章 553200
- 折叠
摘要
目的 比较来曲唑低剂量序贯递增与恒量治疗多囊卵巢综合征(PCOS)不孕症的临床效果,为临床用药提供参考.方法 选取 2023 年 3 月至10 月赫章县人民医院收治的40 例PCOS不孕症患者为研究对象,采用随机抽签法分为观察组(22 例)与对照组(18 例).观察组采用来曲唑低剂量序贯递增治疗,对照组采用来曲唑恒量治疗,比较两组卵泡成熟天数、人绒毛膜促性腺激素(HCG)日子宫内膜厚度、优势卵泡数量、HCG日≥18 mm卵泡数及生化妊娠、临床妊娠、自然流产发生率.结果 两组卵泡成熟天数、HCG日子宫内膜厚度比较,差异无统计学意义(P>0.05);观察组HCG日≥18 mm卵泡数和优势卵泡数量低于对照组,差异有统计学意义(P<0.05);两组生化妊娠率、临床妊娠率和自然流产率比较,差异无统计学意义(P>0.05).结论 来曲唑低剂量序贯递增治疗PCOS不孕症,能够降低HCG日≥18 mm卵泡数和优势卵泡数量,是一种更可行的诱导排卵方案.
Abstract
Objective To compare the clinical effect of low dose sequential increase and constant dose of Letrozole in the treatment of polycystic ovary syndrome(PCOS)infertility,and to provide reference for clinical medication.Methods A total of 40 patients with PCOS infertility admitted to Hezhang County People's Hospital from March to October 2023 were selected as the research objects,and they were divided into observation group(22 cases)and control group(18 cases)by random lottery method.The observation group was treated with low dose of Letrozole sequential increase,and the control group was treated with constant dose of Letrozole.The days of follicle maturation,endometrial thickness on the day of human chorionic gonadotropin(HCG),the number of dominant follicles,the number of follicles≥18 mm on the day of HCG,and the incidence of biochemical pregnancy,clinical pregnancy,and spontaneous abortion were compared between the two groups.Results There were no significant differences in the days of follicle maturation and endometrial thickness on the day of HCG between the two groups(P>0.05).The number of follicles≥18 mm on the day of HCG and dominant follicles in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in biochemical pregnancy rate,clinical pregnancy rate,and spontaneous abortion rate between the two groups(P>0.05).Conclusion Letrozole low dose sequential increase therapy for PCOS infertility can reduce the number of follicles≥18 mm on the day of HCG and dominant follicles,which is a more feasible ovulation induction scheme.
关键词
多囊卵巢综合征/不孕症/来曲唑/序贯递增/诱导排卵Key words
Polycystic ovary syndrome/Infertility/Letrozole/Sequentially increase/Induced ovulation引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据