Objective To explore the clinical effect of Allylestradiol combined with Ritodrine in the treatment of elderly primipara with threatened premature birth.Methods A total of 82 elderly primiparas diagnosed with threatened premature birth in Sihui People's Hospital from June 2021 to June 2023 were selected as the research objects.They were divided into control group and observation group by random number table method,with 41 cases in each group.The control group was treated with Ritodrine,and the observation group was treated with Allylestradiol+Ritodrine.The total effective rate of treatment,the success rate of fetal protection,and the occurrence of adverse drug reactions were compared between the two groups.Results The total effective rate of the observation group(95.12%)was higher than that of the control group(80.49%)(P<0.05).The success rate of fetal protection in the observation group was higher than that in the control group,and the gestational age of delivery was greater than that in the control group(P<0.05).There was no significant difference in the incidence of perinatal adverse outcomes and adverse drug reactions between the two groups(P>0.05).Conclusion The combination treatment of Allylestradiol and Ritodrine can improve the pregnancy outcome of elderly primipara with threatened premature birth,which is worth popularization and application.