摘要
目的 探讨二甲双胍联合胰岛素对妊娠糖尿病患者的治疗效果.方法 选取枣庄市妇幼保健院2021年1月至 2022 年12 月收治的妊娠糖尿病患者,共 80 例,采用随机数字表法分为两组,每组各 40 例.对照组单用胰岛素,观察组采用二甲双胍联合胰岛素,比较两组治疗效果、剖宫产率、母婴不良结局、血糖水平、胰岛功能.结果 观察组的治疗总有效率相较于对照组高(P<0.05);观察组剖宫产率及产后出血、产褥感染、胎儿窘迫、巨大儿、早产发生率低于对照组(P<0.05);观察组治疗后空腹血糖、空腹C肽、餐后 2 h血糖、最大血糖波动幅度和糖化血红蛋白水平低于对照组(P<0.05);观察组治疗后胰岛β细胞功能指数高于对照组,胰岛素抵抗指数、空腹胰岛素水平低于对照组(P<0.05).结论 二甲双胍联合胰岛素治疗妊娠糖尿病有较好的效果.
Abstract
Objective To investigate the clinical effect of Metformin combined with insulin in the treatment of gestational diabetes mellitus.Methods Eighty patients with gestational diabetes mellitus admitted to Zaozhuang Maternal and Child Health Care from January 2021 to December 2022 were selected and divided into two groups using the random number table method,with 40 cases in each group.The control group was treated with insulin alone,and the observation group was treated with Metformin combined with insulin.The therapeutic effect,cesarean section rate,maternal and infant adverse outcomes,blood glucose level,and islet function were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).The cesarean section rate and the incidence of postpartum hemorrhage,puerperal infection,fetal distress,macrosomia,and premature birth in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of fasting blood glucose,fasting C-peptide,postprandial blood glucose,maximum blood glucose fluctuation range,and glycosylated hemoglobin in the observation group were lower than those in the control group(P<0.05).After treatment,the homeostasis model assessment-β of the observation group was higher than that of the control group,and the homeostasis model assessment-insulin resistance and fasting insulin level were lower than those of the control group(P<0.05).Conclusion Metformin combined with insulin has a good effect in the treatment of gestational diabetes mellitus.
维普
万方数据