产前母体及父体因素对儿童孤独症谱系障碍影响机制的研究进展
Research progress on the mechanism of prenatal maternal and paternal factors affecting children with autism spectrum disorder
杨丹 1热娜·买买提2
作者信息
- 1. 新疆医科大学第一附属医院儿科学院,新疆乌鲁木齐 830000
- 2. 新疆医科大学第一附属医院儿童保健科,新疆乌鲁木齐 830000
- 折叠
摘要
近年来,国内外关于产前母体因素对儿童孤独症谱系障碍(ASD)发病机制的研究取得了 一定的进展,认为ASD是遗传因素和环境因素共同作用导致大脑发育异常.然而父体影响因素的研究较少,深入了解遗传因素与产前因素在ASD发病机制中的因果关系以及相互作用尤为重要.本文就国内外产前母体及父体因素、环境相互作用对ASD影响机制的研究进行综述,为全面认识本病提供参考.
Abstract
In recent years,research both at home and abroad about prenatal maternal factors on the pathogenesis of children with autism spectrum disorder(ASD)has made some progress,and it is believed ASD is the combination of genetic factors and environmental factors resulting in abnormal brain development.However,there are few researches on paternal factors,so it is particularly important to deeply understand the causal relationship and interaction between genetic factors and prenatal factors in the pathogenesis of ASD.This article reviews the research on the mechanism of the interaction between maternal and paternal factors and the environment on ASD at home and abroad,so as to provide reference for a comprehensive understanding of the disease.
关键词
儿童/孤独症谱系障碍/母体免疫激活/父体因素/遗传Key words
Children/Autism spectrum disorder/Maternal immune activation/Paternal factor/Genetic引用本文复制引用
基金项目
新疆维吾尔自治区创新环境(人才、基地)建设专项——科技创新基地建设(资源共享平台建设)项目(PT2306)
出版年
2024
国家科技期刊平台
NSTL
万方数据