Objective To explore the application effect of different position nursing in premature infants.Methods A total of 70 premature infants admitted to the First People's Hospital of Kunshan from June 2022 to June 2023 were selected as the research objects.According to the random number table method,they were divided into control group and observation group,with 35 cases in each group.The control group was given the conventional supine position,and the observation group was given the free position.The heart rate,respiratory rate,daily sleep time,and daily increase of milk intake volume were compared between the two groups.Results On the third and seventh days after nursing,the heart rate and respiratory rate of the observation group were lower than those of the control group,the daily sleep time was longer than that of the control group,and the daily increase of milk intake volume was more than that of the control group(P<0.05).Conclusion The application of free position in premature infants can improve the heart rate,respiratory rate,sleep time and milk intake volume.