毛细血管渗漏指数联合补体C3对儿童脓毒症早期预后的预测价值
Predictive value of capillary leakage index combined with complement C3 in the early prognosis of sepsis in children
叶国静 1黄海忠 1张红 1邓国雄 1谢培林 1王静1
作者信息
- 1. 广东省惠州市第三人民医院儿科,广东惠州 516002
- 折叠
摘要
目的 探讨毛细血管渗漏指数(CLI)联合补体C3 对脓毒症患儿早期预后的预测价值.方法 回顾性分析 2021年12 月至 2023 年10 月惠州市第三人民医院收治的 50 例脓毒症患儿,按照病情严重程度分为一般脓毒症组(n=32)和脓毒性休克组(n=18).比较两组CLI、补体C3,分析补体C3、CLI与序贯器官功能衰竭(SOFA)评分的关系,单因素、多因素分析脓毒症患儿早期预后的影响因素,采用受试者操作特征(ROC)曲线分析CLI和补体C3 对脓毒症不良预后的预测作用.结果 脓毒性休克组的CLI高于一般脓毒症组,补体C3 低于一般脓毒症组(P<0.05).补体C3 与SOFA评分呈负相关(r=-0.52,P<0.001),CLI与SOFA评分呈正相关(r=0.49,P<0.001).脓毒症患儿预后不良发生率为42.00%.多因素logistic分析显示,CLI、SOFA、补体C3和Th/Ts是脓毒症预后不良的独立预测因素(P<0.05).ROC曲线分析显示,补体C3联合CLI预测不良预后的曲线下面积为0.874(95%CI:0.847～0.942),约登指数为0.778,预测价值高于单项指标(P<0.05).结论 脓毒症患儿C3、CLI水平明显升高,可作为脓毒症预后评价的指标,且两者联合具有较高的预测价值.
Abstract
Objective To explore the value of capillary leakage index(CLI)combined with complement C3 in predicting the early prognosis of sepsis in children.Methods A retrospective analysis was performed on 50 children with sepsis who were admitted to the Third People's Hospital of Huizhou City from December 2021 to October 2023 and divided into general sepsis group(n=32)and septic shock group(n=18)according to the severity of the disease.The CLI and complement C3 between the two groups were compared,and the relationship between CLI,complement C3 and sequential organ failure assessment(SOFA)score was analyzed.The influencing factors of early prognosis in children with sepsis were analyzed by univariate and multifactorial analysis,and the predictive role of CLI and complement C3 on poor prognosis in sepsis was analyzed using receiver operator characteristic(ROC)curve.Results The septic shock group had higher CLI and lower complement C3 than the general sepsis group(P<0.05).The complement C3 was negatively correlated with SOFA score(r=-0.52,P<0.001),while CLI was positively correlated with SOFA score(r=0.49,P<0.001).The incidence rate of poor prognosis in sepsis was 42.00%.Multifactorial logistic analysis showed that the CLI,SOFA,complement C3,and Th/Ts were independent predictors of poor prognosis in sepsis(P<0.05).ROC curve showed that the area under the curve of complement C3 combined with CLI for predicting poor prognosis was 0.874(95%CI:0.847-0.942),and the Youden index was 0.778.The combined predictive value was higher than that of each index alone(P<0.05).Conclusion There are significant increases in the levels of C3 and CLI in children with sepsis,which can be used as indicators for the prognosis evaluation of sepsis,and their combination has a higher predictive value.
关键词
补体C3/毛细血管渗漏指数/脓毒症Key words
Complement C3/Capillary leakage index/Sepsis引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据