首页|Overinhibition of Mitogen-Activated Protein Kinase Inducing Tau Hyperphosphorylation
Overinhibition of Mitogen-Activated Protein Kinase Inducing Tau Hyperphosphorylation
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To reveal the relationship between mitogen-activated protein kinase (MAPK) and tau phosphorylation, we used different concentration of PD98059, an inhibitor of MEK (MAPK kinase), to treat mice neuroblastma (N2a) cell line for 6 h. It showed that the activity of MAPK decreased in a dose-dependent manner. But Western blot and immunofluorescence revealed that just when the cells were treated with 16 μmol/L PD98059, tau was hyperphosphorylated at Ser396/404 and Ser199/202 sites. We obtained the conclusion that overinhibited MAPK induced tau hyperphosphorylation at Ser396/404 and Ser199/202 sites.
mitogen-activated protein kinase (MAPK)tauAlzheimer's disease
LI Hong-lian、CHEN Juan、LIU SHI-JIE、ZHANG Jia-yu、WANG Qun、WANG Jian-zhi
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Department of Pathophysiology, Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430030, China
NETL
NSTL
万方数据
维普
