首页|Discovery and Content Variation Analysis of Fibrinolytic Enzyme in Semen Sojae Praeparatum Fermentation

Discovery and Content Variation Analysis of Fibrinolytic Enzyme in Semen Sojae Praeparatum Fermentation

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A strong fibrinolytic activity was demonstrated in the Semen Sojae Praeparatum (SSP),which is a famous traditional Chinese medicine.To study the activities and dynamic changes of fibrinolytic enzyme,standard fibrin plate was used to determine the fibrinolytic activity.For the first time fibrinolytic enzyme was found during the fermentation of SSP and the fibrinolytic activities of samples were shown to increase significantly over time.In the "yellow cladding" stage,the fibrinolytic activity was 619.75 IU/g.On day 6,12 and 15 of the "secondary fermentation" stage,the fibrinolytic activity was 711.49 IU/g,866.67 IU/g,1 022.31 IU/g,respectively.The results indicate that fibrinolytic enzyme was generated during the fermentation of SSP and it displayed increasing activity which peaked at the "secondary fermentation" stage.The fibrinolytic enzyme was found to not only degrades fibrin directly,but also activate plasminogen to do so.

Semen Sojae Praeparatumfibrinolytic enzymecardiovascular diseasesthrombolytic effectfunctional foods

WENG Meizhi、DENG Xiongwei、CHEN Qingfeng、WANG Liyuan、XIE Xiaomei

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College of Traditional Chinese Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004,Jiangxi, China

Hongdu Chinese Medical Hospital, Nanchang 330008,Jiangxi, China

Key Laboratory of Modem Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine,Nanchang 330004, Jiangxi, China

Supported by the National Natural Science Foundation of ChinaNatural Science Foundation of Jiangxi ProvinceJiangxi Provincial Health and Family Planning Commissionand the Natural Science Foundation of Jiangxi University of Traditional Chinese Medicine

81660664GJJ1608582017Z0162014BS013

2020

武汉大学自然科学学报(英文版)
武汉大学

武汉大学自然科学学报(英文版)

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影响因子：0.066
ISSN：1007-1202
年,卷(期)：2020.25(1)
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