首页|Single-Cell Sequencing: Technical Development and Applications in Neuroscience Research
Single-Cell Sequencing: Technical Development and Applications in Neuroscience Research
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Understanding the structure and function of life requires the study of its basic constituent unit—ells.Cell bio-function depends largely on the coordinated expression of different genes.Traditional sequencing methods (such as DNA sequencing,and bulk RNA-seq) are performed on cell populations or tissue samples,in which biological differences between cells can be easily obscured by sample averaging and technical noises.Single-cell sequencing,an emerging technique in recent years,contributes extensively to understanding biological phenomena and studying the mechanism of diseases.Sequencing the genome of individual cells could reveal gene mutations,while single-cell transcriptome sequencing helps uncover the expression variability of genes,and most importantly,heterogeneous cells from the same samples.In this review,we will give an overview of the single-cell sequencing technique and its current applications in one of the most popular research fields: neuroscience research.
single-cell sequencingtechniqueneuroscience
YANG Dan、LIU Hanqing
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Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China
Department of Thyroid and Breast Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China
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