首页|Progress in Research on the Role of Angiomotins in Cancer

Progress in Research on the Role of Angiomotins in Cancer

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Cancer is a major public health problem worldwide and its overall morbidity and mortality have been increasing every year.The growth,invasion and metastasis of cancer are vital traits of malignancy causing extreme difficulties in therapeutic management.These behavioral characteristics of cancer are closely related to tumor angiogenesis.The argument was put forward that tumorigenesis depended on the formation of new blood vessels,which gained insight into a promising treatment strategy for cancer based on the inhibition of tumor angiogenesis.To date,many new therapeutic strategies targeting tumor vessels are universally accepted and become a hotspot in oncology research.Angiomotin (Amot),encoded by Amot gene,is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta.During the formation of new blood vessels,Amot may play an inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors.In this review,we summarized the structure and function of Amot,and its mechanism and research progress in cancer.

AngiomotinAngiomotin-like 1Angiomotin-like 2Hippocancer

XU Fei、LI Wenhui、CHEN Linjun、FANG Wen juan

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Department of Microbiology and Immunology, Shanghai University of Medicine & Health Sciences, Shanghai 201318,China

Collaborative Innovation Center, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China

National Natural Science Foundation of Chinaand the Produce-Learn-Research Projects of Shanghai University of Medicine & Health Sciencesand the Produce-Learn-Research Projects of Shanghai University of Medicine & Health Sciences

81804096B1-0200-19-311144B3-0200-20-311008-11

2020

10.19823/j.cnki.1007-1202.2020.0048

武汉大学自然科学学报(英文版)
武汉大学

武汉大学自然科学学报(英文版)

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影响因子：0.066
ISSN：1007-1202
年,卷(期)：2020.25(5)
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