首页|Predictive Value of High Mobility Group Box-1 and miR-146b in Septic Shock Patients

Predictive Value of High Mobility Group Box-1 and miR-146b in Septic Shock Patients

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In the face of the elevated incidence and mortality rate of septic shock in the ICU,this retrospective study seeks to investigate the indicative and predictive value of high-mobility group box 1(HMGB1)and miR-146b in patients with septic shock.Quantitative RT-PCR was employed in this study to quantify the HMGB1 and miR-146b levels in plasma samples obtained from the patient group and healthy controls.The investigation involved the comparison between the two groups and tracking changes in the patient group over time.The finding revealed that upon admission,the patient group exhibited markedly elevated relative expression levels of HMGB1,which sub-sequently decreased over time.Conversely,the patient group displayed significantly reduced relative expression levels of miR-146b upon admission,which subsequently increased over time compared to the control group.Receiver operating characteristic(ROC)curves showed good predictive value for HMGB1 and miR-146b.The experimental results suggest that HMGB1 and miR-146b serve as valuable and con-venient biomarkers for evaluating the severity of septic shock and predicting mortality.Additionally,it is proposed that serum miR-146b may be inducible and potentially exerts a negative regulatory effect on the expression of HMGB1.

septic shockfeedback loophigh mobility group box-1miR-146bdisease severity

FENG Jun、SHAO Shasha、LIU Junya、PAN Yongjun、YIN Huimei、WANG Junshuai

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Department of Emergency Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China

Department of Critical Care Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China

Department of Critical Care Medicine,Southern University of Science and Technology Hospital,Shenzhen 518055,Guangdong,China

Department of Emergency Medicine,People's Hospital of Bortala Mongol Autonomous Prefecture,Bole 833400,Xinjiang,China

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Natural Science Foundation of Hubei ProvinceScientific Research Project of Hubei Pathophysiological SocietyMedical Service Capacity Building and Health Personnel Training Project of the Central GovernmentKey Project of Science and Technology Program of Nanshan District,ShenzhenWu Jieping Medical Foundation Clinical Research Project

2021CFB0262021HBAP002New Finance Society[2022]255NS2022014320.6750.2021-11-12

2024

10.1051/wujns/2024291085

武汉大学自然科学学报(英文版)
武汉大学

武汉大学自然科学学报(英文版)

CSTPCD
影响因子：0.066
ISSN：1007-1202
年,卷(期)：2024.29(1)
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