Chemical Constituents of Petroleum Ether Extract from the Rhizome of Kaempferia galanga L.
Twenty-two compounds were isolated and purified from the petroleum ether extract of the 75％ethanol extract ob-tained from the rhizome of Aromatic ginger(Kaempferia galanga L.).This purification process involved chromatography on silica gel,Sephadex LH-20,ODS,MCI,and RP-HPLC.Based on a thorough examination of physicochemical properties and spectral analyses,the chemical structures of the isolated compounds were identified as(-)-clovane-2,9-diol(1),(-)-4α,7α-aromaden-dranediol(2),caryolane-1,9β-diol(3),15-hydroxy-α-cadinol(4),cryptomeridiol(5),oxyphyllenodiol B(6),(4S,7S)-4-hydroxy-1,10-seco-muurol-5-ene-1,10-dione(7),junipediol(8),guaianediol(9),(-)-(4S,6S)-6-hydroxypiperitone(10),(4S,5R)-5-hydroxypiperitone(11),(4S,5S)-5-hydroxypiperitone(12),(R)-8-hydroxycarvotanacetone(13),(-)-(1R,4S,6S)-1,6-dihydroxy-2-menthene(14),4-methyl-3-(3-oxo-l-butyl)-2-penten-4-olide(15),5-hydroxymethyl-2-furancarboxaldehyde(16),ethyl-trans-p-methoxycinnamat(17),trans-4-methoxycinnamic acid(18),p-hydroxybenzoic acid(19),anise acid(20),methyl-2,3-dihydroxy-3-(4-methoxyphenyl)propanoate(21),ethyl-2,3-dihydroxy-3-(4-methoxyphenyl)propanoate(22).Compounds 1-9 belong to sesquiterpenes,while compounds 10-14 are p-menthane monoterpenes.Notably,compounds 1-16 were isolated from this plant for the first time.
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