多甲氧基黄酮的神经保护作用研究进展
Advances in Neuroprotective Effects of Polymethoxyflavonoids
李虹 1丁平 2李卫岗 3张文生4
作者信息
- 1. 广州中医药大学中药学院,广东广州 510006;京师北中横琴科技研究院有限公司,广东珠海 519031;北京师范大学天然药物教育部工程研究中心,北京 100088
- 2. 广州中医药大学中药学院,广东广州 510006
- 3. 拱北海关技术中心,广东珠海 519000
- 4. 北京师范大学天然药物教育部工程研究中心,北京 100088
- 折叠
摘要
多甲氧基黄酮(polymethoxyflavonoids,PMFs)是从柑橘属植物中提取的一类黄酮成分,生物活性广泛,具有神经保护作用.本文综述了 PMFs在动物和细胞模型中对中枢神经系统损伤(阿尔茨海默病、帕金森病、脑缺血、脂多糖诱导的神经损伤等)的保护和改善作用,并重点阐述其潜在作用机制,旨在深入理解PMFs的药效及分子作用机制,为神经系统相关疾病的预防和治疗提供新的思路.
Abstract
Polymethoxyflavonoids(PMFs),a class of flavonoids extracted from citrus plants,have a wide range of biological activities and neuroprotective effects.This article reviews the protective and ameliorating effects of PMFs on central nervous system injury(Alzheimer's disease,Parkinson's disease,cerebral ischemia,LPS-induced nerve injury,etc.)in animal and cell models,and focuses on its potential mechanism.The aim of this study is to further understand the pharmacodynamics and molecular mechanism of PMFs in deep,so as to provide new ideas for the prevention and treatment of nervous system related diseases.
关键词
多甲氧基黄酮/神经系统损伤/橘红素/川陈皮素/甜橙黄酮/阿尔茨海默病(AD)/帕金森病(PD)Key words
polymethoxyflavonoids/nervous system injury/tangeretin/nobiletin/sinensetin/Alzheimer's disease(AD)/Parkinson's disease(PD)引用本文复制引用
出版年
2024
NETL
NSTL
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