Acute and Sub-Acute Oral Toxicities of Coptis chinensis Inflorescence and Its Alkaloids Mixture
In order to study the safety of Coptis chinensis inflorescence as an edible raw material,the acute and sub-acute oral toxicities of C.chinensis inflorescence extract(CE)and its main alkaloids(MIX)were tested.KM mice were orally administered with 20 000 mg/kg CE or 743.2 mg/kg MIX for 14 days,and no toxicity or mortality was observed.SD rats were orally administered with three different doses of CE(500,1 000,2 000 mg/kg)and the alkaloids mixture(37.16 mg/kg)for 28 days.There was no significant difference detected in animal weight and organ relative weight between the control group and the treat-ment groups.The serum biochemical,hematological and urine parameters of all groups were examined and found to be within the normal ranges.Finally,the main organs did not present any histopathological lesions,and no animal death was observed.Based on these results,the safety of C.chinensis inflorescence as a medicinal and food homologous raw material can be ensured.
Coptis chinensis inflorescencemedicine and food homologyalkaloidacute toxicitysub-acute toxicity
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