Study on Anti-inflammatory Active Components of Codonopsis pilosula produced in Hubei Province
Screening of anti-inflammatory active components in Codonopsis pilosula produced in Hubei Province by using molecular docking technology.The main chemical components were searched in the TCMSP databases,and molecularly docked with 5 tumor related protein using SYBYL software.The active ingredients were screened based on the docking scoring function.The interaction force of protein complexes were analyzed by Discovery studio and Pymol software,and ten active compounds with good binding activity and multi-target activity were screened out.The effects of compound codonopilodiynoside L and ethanol extract on nitric oxide(NO)in cells were detected to further verify the anti-inflammatory activity.
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