首页|医用生物陶瓷的功能性生物适配机制及应用

医用生物陶瓷的功能性生物适配机制及应用

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为了获得满意的临床疗效，优质医用生物陶瓷应该具备怎样的性能一直困扰着广大研究者。自 20 世纪 90年代以来，作者团队致力于研发医用生物陶瓷，从基础科学研究到成果转化，再到临床应用，积累了丰富的研究和应用经验，相继提出了"生物适配"和"精准生物适配"理论。本文围绕"医用生物陶瓷(磷酸钙类材料)的功能性生物适配"这一主题分享本团队的学术研究成果和临床应用经验，从结构适配、降解适配、力学适配、应用适配等四个角度，结合骨科临床应用背景，探讨如何实现其生物适配和设计制造的有效衔接，旨在为医用生物陶瓷的设计、制造、监管和应用提供依据和建议。
Functional Bioadaptability in Medical Bioceramics:Biological Mechanism and Application
The question of what qualities excellent medical bioceramics must possess to ensure satisfactory prognosis for bone healing and reconstruction remains a topic of great interest in both clinical and biomaterial sciences.Our team has been dedicated to researching medical bioceramics since the 1990s,involving basic scientific research,applied translational research,and clinical trials.Consequently,we have amassed a wealth of research and implementation experience.In this article,we aim to explore the subject of"Functional Bioadaptability in Medical Bioceramics",specifically focusing on calcium phosphate-based materials.We summarized how to effectively combine bioadaptability with design and manufacturing of medical bioceramics in the background of orthopedic clinical application,with the following aspects of structural adaptability,degradative adaptability,mechanical adaptability,and application adaptability.Hopefully,some suggestions put forward can ultimately provide valuable insights and recommendations for the design,production,supervision,and application of the upcoming medical bioceramics.

bioceramicsbioadaptabilitymaterial microstructurebiodegradationosteo-regenerationvascularizationperspective

郑嘉乾、卢霄、鲁亚杰、王迎军、王臻、卢建熙

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华南理工大学 国家人体组织功能重建工程技术研究中心,广州 510006

华南理工大学 材料科学与工程学院,广州 510641

上海骨科生物材料技术创新中心,上海 201114

上海贝奥路生物材料有限公司,上海 201114

中国人民解放军空军军医大学 西京医院,骨科,西安 710032

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生物陶瓷 生物适配 材料微结构 生物降解 骨再生 血管化 专题评述

National Key Research and Development Program of ChinaNational Natural Science Foundation of ChinaShanghai Science and Technology Innovation Action Plan

2021YFB38008003200096022S31906500

2024

10.15541/jim20230244

无机材料学报
中国科学院上海硅酸盐研究所

无机材料学报

CSTPCD北大核心
影响因子：0.768
ISSN：1000-324X
年,卷(期)：2024.39(1)
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