Synthesis,Crystal Structures and Antibacterial Activities of Ni(Ⅱ),Co(Ⅱ)Complexes from Amino Acid Schiff Base
Two complexes[NiL_2](CH_3OH)(1) and [CoL_2](CH_3OH)(2) were synthesized,where L is a Schiff base ligand (C_(27)H_(24)ClN_3O_3) was derived from condensation of 1-phenyl-3-methyl-4-(p-chlorbenzyl)-5-pyrazolone with L-Phenylalanine methyl ester.They were characterized by elemental analysis,IR and single crystal X-ray diffraction.The complexes 1 and 2 consist of two individual fragments and a dissociative methanol.Every fragment is a distorted octahedron with four oxygen atoms and two nitrogen atoms.The Schiff base ligand and its complexes have been tested in vitro to evaluate their antibacterial activity against bacteria Escherichia Coli andStaphylococcus Aureus.It has been found that the complex 2 has higher activity than the corresponding free Schiff base ligand and complex 1 against the same bacteria.
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