Advances in positron emission tomography imaging tracers for the central dopamine system
The central dopamine system plays a crucial role in the pathophysiology of various neurobehavioral disor-ders.Positron emission tomography(PET)imaging has been instrumental in studying dopamine biochemical pro-cesses in the living brain.PET imaging utilizes positron-emitting radionuclide 11C/18F-labelled tracers to assess dopa-mine synthesis,vesicle storage,synaptic release,receptor binding,and reuptake processes by binding to specific tar-gets in the dopamine nervous system.This advancement has significantly contributed to research in neurology,psy-chiatry,drug abuse and addiction,and therapeutic drug development.This article provides a comprehensive review of the progress in 11C/18F-labelled PET imaging agents targeting amino acid decarboxylase,dopamine transporters,dopamine receptors,and vesicular monoamine transporters.
NETL
NSTL
万方数据
维普
