首页|具有红色荧光性质的掺硒碳点在生物传感和抗菌中的多功能应用

具有红色荧光性质的掺硒碳点在生物传感和抗菌中的多功能应用

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以易得的苯亚硒酸(BA)和邻苯二胺(o-PDA)作为前体,通过一步水热法成功设计并合成了掺杂硒的碳点(Se-CDs).制备的Se-CDs发出红色波段的荧光,并被用于开发一种检测microRNA-21(miR-21)的灵敏荧光传感器.通过脱氧核糖核酸酶Ⅰ(DNase Ⅰ)介导的信号放大方法,将miR-21的检测限从78 nmol·L-1改进到了6.8 nmol·L-1.此外,Se-CDs对大肠杆菌等革兰氏阴性菌具有理想的抑制活性.
Red-emitting selenium-doped carbon dots for versatile applications in biosensing and antibacterial activities
In this study,we successfully designed and synthesized selenium-doped carbon dots(Se-CDs)using easi-ly available precursors of benzeneseleninic acid(BA)and o-phenylenediamine(o-PDA)through a one-step hydro-thermal method.These Se-CDs emitted red-wavelength fluorescence and were utilized to develop a sensitive fluores-cence sensor for detecting microRNA-21(miR-21).By incorporating deoxyribonuclease Ⅰ(DNase Ⅰ)-mediated signal amplification,the detection limit for miR-21 was improved from 78 to 6.8 nmol·L-1.Furthermore,we observed desirable inhibitory activity of the Se-CDs against Gram-negative bacteria of Escherichia coli(E.coli).

selenium-doped carbon dotsred fluorescencebiosensingmicroRNA-21antibacterial

厉圆圆、卢修联、刘欣雨、张磊、景苏

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南京工业大学化学与分子工程学院,南京 211816

掺硒碳点 红色荧光 生物传感 microRNA-21 抗菌

国家自然科学基金国家自然科学基金江苏省重点研发计划

2217509022374075BE2021712

2024

无机化学学报
中国化学会

无机化学学报

CSTPCD北大核心
影响因子:0.665
ISSN:1001-4861
年,卷(期):2024.40(1)
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