首页|基于双靶向黑色素纳米粒的肿瘤深穿透光声成像

基于双靶向黑色素纳米粒的肿瘤深穿透光声成像

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通过1-(3-二甲基氨基丙基)-3-乙基碳二亚胺和N-羟基丁二酰亚胺反应将透明质酸(hyaluronic acid,HA)和4-羧丁基三苯基溴化膦((4-carboxybutyl)triphenylphosphonium bromide,TPP)分子连接到聚乙二醇-氨基(PEG-NH2)修饰过的黑色素纳米颗粒(melanin nanoparticles,MNP)表面,设计合成了一种具有双靶向能力的黑色素纳米颗粒(MNP-TPP-HA),赋予了黑色素的双靶向能力.体外三维(3D)多细胞肿瘤球荧光成像和活体肿瘤光声成像实验表明MNP-TPP-HA具有优异的肿瘤靶向穿透能力.
Deeply penetrating photoacoustic imaging in tumor tissues based on dual-targeted melanin nanoparticle
A dual-targeting melanin nanoparticle(MNP-TPP-HA)was constructed by grafting the carboxyl groups of hyaluronic acid(HA)and(4-carboxybutyl)triphenylphosphonium bromide(TPP)onto the surface of polyethylene glycol-amino(PEG-NH2)modified MNP based on 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride(EDC)and N-hydroxy succinimide(NHS)reaction,endowing melanin with the ability of dual active targeting.The fluorescence imaging of in vitro three-dimensional(3D)tumor models and in vivo photoacoustic imaging(PAI)all reveal the excellent target penetration ability of MNP-TPP-HA.

dual-targetingmelaninphotoacoustic imagingpenetration ability

曲波涛、王倩、宁晓刚、周雨欣、张瑞平

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山西医科大学基础医学院,太原 030001

山西医科大学法医学院,太原 030001

山西中医药大学中药与食品工程学院,晋中 030619

山西医科大学第一医院放疗科,太原 030001

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双靶向 黑色素 光声成像 穿透能力

国家自然科学基金国家自然科学基金国家万人计划项目Research Project Supported by Shanxi Scholarship Council of ChinaFund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi ProvinceFour Batches of Scientific Research Projects of Shanxi Provincial Health CommissionFour Batches of Scientific Research Projects of Shanxi Provincial Health CommissionFour Batches of Scientific Research Projects of Shanxi Provincial Health CommissionKey Laboratory of Nanoimaging and Drugloaded Preparation of Shanxi Province

8212010801682071987SQ2022RA2A3001182020-177202000062020TD112020SYS152020XM10202104010910010

2024

10.11862/CJIC.20230416

无机化学学报
中国化学会

无机化学学报

CSTPCD北大核心
影响因子：0.665
ISSN：1001-4861
年,卷(期)：2024.40(5)
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