Synthesis,structure,and anticancer activity of two complexes of dimethylglyoxime organotin
Two dimethylglyoxime organotin compounds,bis(tri(2-methyl-2-phenylpropyl)tin)dimethylglyoxime com-plex(C6H5C(CH3)2CH2)3Sn(ON=C(CH3)C(CH3)=NO)Sn(CH2C(CH3)2C6H5)3(1)and di(benzyl)tin oxide,chlorine,butanedione oxime multinuclear complex[μ3-O-((C6H5CH2)2Sn)2(ON=C(CH3)C(CH3)=NOH)(O)Cl]2(2),were syn-thesized.The compounds were characterized by elemental analysis,IR spectroscopy,NMR(1H,13C,and 119Sn),ther-mogravimetric analysis,and single-crystal X-ray diffraction,and quantum chemical ab initio calculation was per-formed for their structure and in vitro anticancer activity were studied for the compounds.The results showed that complex 1 is a central symmetric molecule with double tin nuclei bridged by the ligand dimethylglyoxime,and the tin atoms are distorted tetrahedral configurations with four coordination.Complex 2 is a central symmetric polycy-clic polymerization structure of tetra-tin nuclei bridged by oxygen atoms and dimethylglyoxime,and the tin atoms are five-coordinated distorted triangular bipyramidal configuration and six-coordinated distorted octahedral configu-ration,respectively.In addition,the complexes have stronger inhibitory activity on human liver cancer cells(HUH7),human lung cancer cells(A549),human epidermal cancer cells(A431),human colon cancer cells(HCT-116),and breast cancer cells(MDA-MB-231).CCDC:2234708,1;2234707,2.
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