摘要
合成了 2个丁二酮肟有机锡化合物:双(三(2-甲基-2-苯基丙基)锡)丁二酮肟配合物(C6H5C(CH3)2CH2)3Sn(ON=C(CH3)C(CH3)=NO)Sn(CH2C(CH3)2C6H5)3(1)和二苄基锡氧氯丁二酮肟多核配合物[μ3-O-((C6H5CH2)2Sn)2(ON=C(CH3)C(CH3)=NOH)(O)Cl]2(2).通过元素分析、红外光谱、核磁共振(1H、13C、119Sn)、差热分析和单晶X射线衍射对配合物进行了结构表征,对其结构进行量子化学从头计算,并进行了体外抗癌活性研究.结果显示:配合物1为通过配体丁二酮肟桥联的双锡核中心对称分子,锡原子均为四配位的畸变四面体构型;配合物2为通过氧原子和丁二酮肟配体桥联的四锡核中心对称多环聚合结构,锡原子分别为五配位的畸变三角双锥构型和六配位的畸变八面体构型.配合物对人肝癌细胞(HUH7)、人肺癌细胞(A549)、人表皮癌细胞(A431)、人结肠癌细胞(HCT-116)和人乳腺癌细胞(MDA-MB-231)均有较强的抑制活性.
Abstract
Two dimethylglyoxime organotin compounds,bis(tri(2-methyl-2-phenylpropyl)tin)dimethylglyoxime com-plex(C6H5C(CH3)2CH2)3Sn(ON=C(CH3)C(CH3)=NO)Sn(CH2C(CH3)2C6H5)3(1)and di(benzyl)tin oxide,chlorine,butanedione oxime multinuclear complex[μ3-O-((C6H5CH2)2Sn)2(ON=C(CH3)C(CH3)=NOH)(O)Cl]2(2),were syn-thesized.The compounds were characterized by elemental analysis,IR spectroscopy,NMR(1H,13C,and 119Sn),ther-mogravimetric analysis,and single-crystal X-ray diffraction,and quantum chemical ab initio calculation was per-formed for their structure and in vitro anticancer activity were studied for the compounds.The results showed that complex 1 is a central symmetric molecule with double tin nuclei bridged by the ligand dimethylglyoxime,and the tin atoms are distorted tetrahedral configurations with four coordination.Complex 2 is a central symmetric polycy-clic polymerization structure of tetra-tin nuclei bridged by oxygen atoms and dimethylglyoxime,and the tin atoms are five-coordinated distorted triangular bipyramidal configuration and six-coordinated distorted octahedral configu-ration,respectively.In addition,the complexes have stronger inhibitory activity on human liver cancer cells(HUH7),human lung cancer cells(A549),human epidermal cancer cells(A431),human colon cancer cells(HCT-116),and breast cancer cells(MDA-MB-231).CCDC:2234708,1;2234707,2.
基金项目
湖南省教育厅优秀青年项目(23B0669)
湘江上游重金属污染监测与治理湖南省工程研究中心开放基金项目(2023HSKFJJO11)
湖南省应用特色学科基金()
湖南省高校科技创新团队支持计划()
国家、湖南省和衡阳师范学院大学生创新创业训练计划()
NETL
NSTL
万方数据