Construction,crystal structures,and biological activities of two LnⅢ3 complexes
Two new trinuclear Ln-based complexes with the formula[Ln3(dbm)5(L)2(CH3OH)2]·CH2Cl2(Ln=Pr(1),Ho(2);Hdbm=dibenzoylmethane)have been constructed via the solvothermal method by using a polydentate Schiff base ligand H2L(H2L=(E)-6-(hydroxymethyl)-N'-((6-methoxypyridin-2-yl)methylene)picolinohydrazide)reacting with Ln(dbm)3·2H2O.Single-crystal X-ray diffraction reveals that complexes 1 and 2 are isostructural,and their structures are mainly composed of three Ln(Ⅲ)ions,five dbm-ions,two L2-ions,two coordinated CH3OH molecules,and one lattice CH2Cl2 molecule.The three central Ln(Ⅲ)ions are connected by four µ2-O atoms forming a folded Ln3 core.Notably,complexes 1 and 2 show promising antibacterial activity and exhibit stronger bacteriostatic activities compared to their precursor components.Additionally,their interaction with calf thymus DNA(ctDNA)was studied using ultraviolet spectroscopy,cyclic voltammetry,and fluorescence spectroscopy,demonstrating their ability to bind to ctDNA mainly by intercalation.CCDC:2258496,1;2258495,2.
lanthanide complexesSchiff base ligandcrystal structuresbiological activitiesDNA-binding
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