Targeting imaging and detection of ovarian cancer cells based on fluorescent magnetic carbon dots
Fluorescent magnetic gadolinium-doped carbon dots(Gd-CDs)were prepared using a high-temperature carbonization method.The prepared Gd-CDs emitted bright green fluorescence with a fluorescence quantum yield of 32.6％and a T1 relaxation efficiency of up to 9.02 L·mmol-1·s-1.By conjugating with the ovarian cancer-specific antibody Anti-HE4,the resulting Anti-HE4/Gd-CDs nanoprobes could perform specific fluorescent imaging and T1-weighted imaging of SKOV-3 ovarian cancer cells.The fluorescence intensity was proportional to the concentration of SKOV-3 cells,with a detection limit of 658 cell·mL-1.This method was applied to the detection of SKOV-3 cells in blood samples.
gadolinium-doped carbon dotstargeting probefluorescence imagingmagnetic resonance imagingovarian cancer cell
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维普
