首页|磁性纳米Fe3O4的氧化共沉淀法制备及催化性能

磁性纳米Fe3O4的氧化共沉淀法制备及催化性能

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以单一 Fe2+作为铁源,0。4%的H2O2为氧化剂,NaOH为沉淀剂,采用氧化共沉淀法制备了尺寸为7 nm的Fe3O4颗粒。为进一步体外模拟肿瘤饥饿治疗,设计了一个包含5 mL(10 μg·mL-1)的葡萄糖氧化酶和15 mL(5mg·mL-1)葡萄糖溶液的体系,以探究纳米Fe3O4的类过氧化氢酶(CAT)与类过氧化物酶(POD)催化性能的最适条件。结果表明:在1 mg·mL-1 pH=5。0时,纳米Fe3O4的类CAT活性能推动葡萄糖氧化反应的反应速度增加、限度增大;pH=5。0时,纳米Fe3O4的类POD活性更好,能高效率催化H2O2产生活性氧。
Preparation and catalytic performance of magnetic nano iron oxide by oxidation co-precipitation method
Iron oxide particles with a size of 7 nm were prepared by the oxidation co-precipitation method using Fe2+as an iron source,0.4%H2O2 as an oxidant,and NaOH as a precipitator.This experiment further simulated tumor starvation therapy in vitor:in 5 mL(10 μg·mL-1)of glucose oxidase and 15 mL(5 mg·mL-1)of glucose solution sys-tem,to explore the optimal conditions for the catalytic performance of catalase(CAT)-like and peroxidase(POD)-like of nano ferrous oxide.The results showed that under 1 mg·mL-1,at pH=5.0,the CAT-like activity of nano Fe3O4 can promote an increase in the reaction rate and limit of glucose oxidation reaction;at pH=5.0,the POD-like activi-ty of nano iron oxide was better.It can catalyze hydrogen peroxide to produce reactive oxygen species with high effi-ciency.

nano iron oxideoxidation co-precipitation methodcatalytic performancetumor starvation therapyreactive oxygen species

侯思宇、李玮瑶、刘家东、王斐、柳雯思、杨静、张莹

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沈阳药科大学,本溪 117004

纳米Fe3O4 氧化共沉淀法 催化性能 肿瘤饥饿治疗 活性氧

辽宁省教育厅基本科学研究项目辽宁省普通高等教育本科教学改革研究项目沈阳药科大学大学生创新创业项目沈阳药科大学大学生创新创业项目

LJKMZ2022136152810163X202310163108X202310163106

2024

无机化学学报
中国化学会

无机化学学报

CSTPCD北大核心
影响因子:0.665
ISSN:1001-4861
年,卷(期):2024.40(8)