Iron oxide particles with a size of 7 nm were prepared by the oxidation co-precipitation method using Fe2+as an iron source,0.4％H2O2 as an oxidant,and NaOH as a precipitator.This experiment further simulated tumor starvation therapy in vitor:in 5 mL(10 μg·mL-1)of glucose oxidase and 15 mL(5 mg·mL-1)of glucose solution sys-tem,to explore the optimal conditions for the catalytic performance of catalase(CAT)-like and peroxidase(POD)-like of nano ferrous oxide.The results showed that under 1 mg·mL-1,at pH=5.0,the CAT-like activity of nano Fe3O4 can promote an increase in the reaction rate and limit of glucose oxidation reaction;at pH=5.0,the POD-like activi-ty of nano iron oxide was better.It can catalyze hydrogen peroxide to produce reactive oxygen species with high effi-ciency.
关键词
纳米Fe3O4/氧化共沉淀法/催化性能/肿瘤饥饿治疗/活性氧
Key words
nano iron oxide/oxidation co-precipitation method/catalytic performance/tumor starvation therapy/reactive oxygen species
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